Idebenone – a new drug for patients with Leber's hereditary optic neuropathy
نویسندگان
چکیده
Leber's Hereditary Optic Neuropathy is a rare disease caused by mutation in the mitochondrial DNA. It appears most often young men, leading to profound, permanent loss of vision short time. There no specific treatment for this condition.Idebenone medicine that administered patients with hereditary optic neuropathy improves or stops deterioration vision. Increasing number people during therapy and duration will allow future answer question, whether drug effective safe larger group patients.
منابع مشابه
Idebenone treatment in Leber's hereditary optic neuropathy.
Valerio Carelli, MD, PhD, Chiara La Morgia, MD, Maria Lucia Valentino, MD, Giovanni Rizzo, MD, PhD, Michele Carbonelli, MD, Anna Maria De Negri, MD, Federico Sadun, MD, Arturo Carta, MD, Silvana Guerriero, MD, Francesca Simonelli, MD, Alfredo A Sadun, MD, PhD, Divya Aggarwal, MD, Rocco Liguori, MD, Patrizia Avoni, MD, PhD, Agostino Baruzzi, MD, Massimo Zeviani, MD, PhD, Pasquale Montagna, MD, P...
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BACKGROUND The authors investigated the correlation of protan and tritan color vision with disease characteristics in Leber hereditary optic neuropathy (LHON). The authors also characterized the therapeutic potential of idebenone in protecting patients from developing dyschromatopsia in LHON. METHODS Color contrast data of 39 LHON patients participating in a randomized, double-blind placebo-c...
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we studied 74 patients with lebers hereditary optic neuropathy (lhon) to investigate causative mtdna mutations (g3460a, g11778a, t14484c, g4459a) in iranian lhon patients. fifty two patients carried the mitochondrial dna (mtdna) g11778a mutation, while one had the t14484c mutation 4 patients had the g3460a mutation and one had the g14459a mutation. our results showed a similarity in the pattern...
متن کاملProgressive auditory neuropathy in patients with Leber's hereditary optic neuropathy.
OBJECTIVE To investigate auditory neural involvement in patients with Leber's hereditary optic neuropathy (LHON). METHODS Auditory assessment was undertaken in two patients with LHON. One was a 45 year old woman with Harding disease (multiple-sclerosis-like illness and positive 11778mtDNA mutation) and mild auditory symptoms, whose auditory function was monitored over five years. The other wa...
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ژورنال
عنوان ژورنال: Ophtha Therapy
سال: 2021
ISSN: ['2543-9987', '2353-7175']
DOI: https://doi.org/10.24292/01.ot.300321.3